Thermo Fisher Scientific KCNH2 Polyclonal Antibody
KCNH2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC에 사용 가능하며, Human, Mouse, Rat 반응성. Lyophilized 형태로 제공되며, 연구용으로 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:300–1:2,000
Immunohistochemistry (IHC)
- Tested Dilution: 1:300–1:2,000
Miscellaneous (PubMed)
- Publications: 2 available
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from amino acid region 850–900 of human KCNH2 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The antigen is homologous in mouse and rat.
- Specificity: KCNH2.
Target Information
Human ether-a-go-go related gene (HERG) encodes the pore-forming alpha subunit of the delayed rectifier potassium channel IKr.
Two N-terminal splice variants exist: isoform 1 alpha (full-length) and isoform 1 beta (shorter, lacking PAS motif).
Isoform 1 beta deactivates faster than isoform 1 alpha.
C-terminal residues contribute to channel expression and gating, including voltage-dependent activation.
HERG is expressed mainly in the heart, more abundantly in ventricles than atria.
Mutations in HERG cause beat-to-beat variability and early after depolarization, associated with long QT syndrome type 2 and short QT syndrome type 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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