Thermo Fisher Scientific KCNH2 Polyclonal Antibody
KCNH2 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC에 사용 가능. Human, Mouse, Rat 반응성. 동결건조 형태로 제공되며, 4°C 단기 보관 및 -20°C 장기 보관 권장. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 10–50 µg/mL | - |
| Immunohistochemistry (IHC) | 10–50 µg/mL | - |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from amino acid region 850–900 of human KCNH2 conjugated to a blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C for short term. For long-term storage, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 500 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The antigen is homologous in mouse and rat.
- Specificity: KCNH2.
Target Information
The human ether-a-go-go related gene (HERG) encodes the pore-forming alpha subunit of the delayed rectifier potassium channel IKr. There are two N-terminal splice variants of HERG: the full-length isoform 1 alpha and the shorter isoform 1 beta. Isoform 1 beta lacks the PAS motif and deactivates at a faster rate than isoform 1 alpha. Residues within the C-terminal region play a role in channel expression and gating, including voltage-dependent activation. HERG is expressed in the heart, with higher expression in ventricles than in atria. Mutations in HERG are associated with inheritable long QT syndrome type 2 and short QT syndrome type 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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