Thermo Fisher Scientific CAS Recombinant Rabbit Monoclonal Antibody (ARC1856)
Recombinant rabbit monoclonal antibody targeting human Exportin 2 (XPO2). Validated for WB and ELISA applications. High purity via affinity chromatography. Supplied as liquid form with 0.5 mg/mL concentration. Suitable for human and mouse samples.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Concentration: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC1856 |
| Immunogen | Synthetic peptide corresponding to amino acids 872–971 of human Exportin 2 (XPO2, P55060) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897749 |
Product Specific Information
- Positive Samples: HeLa, 293T, Jurkat, Mouse testis, Mouse thymus
- Immunogen Sequence:
LIGLFELPED DTIPDEEHFI DIEDTPGYQT AFSQLAFAGK KEHDPVGQMV NNPKIHLAQS LHKLSTACPG RVPSMVSTSL NAEALQYLQG YLQAASVTLL
Target Information
Proteins carrying a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha, which must then return to the cytoplasm. The encoded protein binds strongly to NLS-free importin-alpha, released in the cytoplasm by RANBP1 and RANGAP1. It may also play roles in apoptosis and cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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