Thermo Fisher Scientific Phospho-GP130 (Ser782) Polyclonal Antibody
Phospho-GP130 (Ser782) 폴리클로날 항체로, 인간 및 생쥐 시료에서 인산화된 GP130을 검출. Western blot과 IHC(파라핀) 적용 가능. 고순도 정제된 액상 형태로 제공되며, PBS/glycerol 버퍼에 보존. 연구용 전용 제품.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human IL6ST (Accession P40189), corresponding to amino acid residues around phosphorylated Ser782 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2817179 |
Product Specific Information
Antibody detects endogenous levels of CD130/gp130 only when phosphorylated at Ser782.
Target Information
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM).
This protein functions as part of the cytokine receptor complex, and its activation depends upon cytokine binding to receptors.
vIL6, encoded by the Kaposi sarcoma-associated herpesvirus, can bypass IL6R and directly activate this protein.
Knockout studies in mice indicate a critical role in regulating myocyte apoptosis.
Alternatively spliced transcript variants encoding distinct isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-105780_GP130_P40189-1_Rabbit.svg, PA5-105780_GP130_P40189-1_Rabbit_PDP.jpeg)
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