Thermo Fisher Scientific Neurofibromin Polyclonal Antibody
Rabbit polyclonal antibody targeting human neurofibromin for WB and IHC applications. High specificity with antigen affinity purification. Supplied as liquid form at 0.5 mg/mL with sodium azide preservative. Ideal for research use in neurobiology and p...
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Thermo Fisher Scientific Neurofibromin Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide surrounding the epitope -PTSPY- without phosphorylation at human neurofibromin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Mouse hypoxic brain
Target Information
The protein encoded by this gene is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. It is a mannose-specific lectin and a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in this gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined factor V–factor VIII deficiency, a rare autosomal recessive disorder in which both coagulation factors V and VIII are diminished.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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