Thermo Fisher Scientific SNAP23 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

PA1-738 detects synaptosomal-associated protein 23 (SNAP-23) from human, mouse, and rat samples.
It has been successfully used in Western blot and immunoprecipitation procedures.
By Western blot, this antibody detects an approximately 23 kDa protein representing SNAP-23 from rat/mouse brain protein extract and HeLa cell lysates.

The immunizing peptide corresponds to amino acid residues 193–210 from mouse SNAP-23 protein.
PA1-738 immunizing peptide (Cat. # PEP-147) is available for use in neutralization and control experiments.

Target Information

Specificity of vesicular transport is regulated by the interaction between vesicle-associated membrane proteins (synaptobrevin/VAMP) and target membrane proteins (syntaxin).
Together with SNAP25, these proteins form a complex that acts as a binding site for the membrane fusion machinery.

Synaptobrevin/VAMP and syntaxin are involved in vesicular transport in most cells, while SNAP25 is largely brain-specific.
SNAP23, a homolog of SNAP25, is ubiquitously expressed and facilitates vesicle docking and fusion in other tissues.
It binds tightly to multiple syntaxins and synaptobrevins/VAMPs, acting as an essential component of the high-affinity receptor for membrane fusion machinery.
Two alternative transcript variants encoding different isoforms have been described for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.