Thermo Fisher Scientific MerTK (Innate Immune Checkpoint) Monoclonal Antibody (MERTK, 3022)
인간 MERTK 단백질을 인식하는 Mouse IgG2a 단일클론 항체로 면역조직화학(IHC) 및 펩타이드 배열 분석에 적합. 비결합형 액상 형태로 제공되며, PBS 버퍼에 보존제 없이 저장. 세포 생존, 이동 및 식세포 작용 연구에 활용 가능.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MERTK, 3022 |
| Immunogen | Recombinant human MERTK protein fragment (around aa 55–148) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): Incubate antibody for 30 min at room temperature.
- Staining of formalin-fixed tissues requires heating sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 min at 95°C, followed by cooling at room temperature for 20 min.
Target Information
MERTK (cMER) is a tyrosine kinase proto-oncogene involved in retinal pigment epithelium (RPE) phagocytosis, which is related to retinal disease. It regulates cell survival, migration, differentiation, and efferocytosis. Ligand binding induces autophosphorylation, enabling downstream signaling via GRB2 or PLCG2, and activation of MAPK1, MAPK2, FAK/PTK2, or RAC1. MERTK signaling contributes to macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization, and RPE-mediated rod outer segment phagocytosis. It also inhibits Toll-like receptor (TLR)-mediated innate immune responses by activating STAT1, leading to selective induction of SOCS1 and SOCS3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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