Thermo Fisher Scientific Phospho-ITGB1 (Thr789) Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

This antibody detects endogenous protein at a molecular weight of approximately 90 kDa.
Purity is >95% by SDS-PAGE.

Target Information

ITGB1 (Integrin Subunit Beta 1, beta1 integrin subunit, GPIIa, CD29) is a 110 kDa cell surface glycoprotein widely expressed by various cells, including all leukocytes. ITGB1 forms non-covalently linked heterodimers with at least six different alpha chains (α1–α6, CDa–f), determining the binding properties of beta1 (VLA) integrins.

ITGB1 acts as a cell adhesion molecule found on platelets, as the common beta subunit of the very late activation antigen (VLA), and as part of complexes binding to extracellular matrix proteins.

Decreased expression of ITGB1 correlates with multidrug resistance in tumor cells exposed to anti-tumor drugs. It is upregulated in leukocytes during emigration and extravascular migration, playing a critical role in immune cell trafficking.

ITGB1 also regulates tissue damage and inflammatory bowel disease symptoms. Through an ITGB1-dependent mechanism, fibronectin and type I collagen enhance cytokine secretion of human airway smooth muscle cells in response to IL-1β.

More than eight beta subunits with numerous splice variants exist in mammals. Two major forms of integrin beta1—beta1A and beta1D—differ by 13 amino acids. Beta1A is present in all tissues except cardiac and skeletal muscle, which express beta1D.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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