Thermo Fisher Scientific HINT1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total HINT1.

Target Information

Histidine triad nucleotide-binding protein 1 (HINT1) is a member of the histidine triad (HIT) protein family, a group of small nucleotide-binding and -hydrolyzing proteins.
HINT1 interacts with several diverse proteins and has been suggested to have tumor suppressive activities.
HINT1 catalyzes the hydrolysis of adenosine 5'-monophoramidate substrates such as AMP-morpholidate, though its enzymatic function does not appear to play a role in tumor suppression.
Recent experiments demonstrate that HINT1 forms a complex with POSH and JNK in vivo, inhibiting AP-1 activity and c-Jun phosphorylation, contributing to tumor suppressor activity.
Other studies suggest HINT1 may be a candidate gene for schizophrenia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일명: PA5-115357_HINT1_P49773-1_Rabbit.svg, PA5-115357_HINT1_P49773-1_Rabbit_PDP.jpeg)