Thermo Fisher Scientific INSR alpha Recombinant Mouse Monoclonal Antibody (Fab 83-7)
인슐린 수용체 알파 서브유닛을 인식하는 마우스 재조합 단클론 항체입니다. HEK293 세포에서 발현된 IgG1 아이소타입으로, in vitro assay에 적합합니다. 1 mg/mL 농도의 액상 형태로 제공되며, 단백질 A로 정제되었습니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
- In vitro Assay (IV): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | Fab 83-7 |
| Immunogen | This antibody was raised by immunizing mice with IM-9 lymphocytes followed by purified insulin receptor. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_3074500 |
Product Specific Information
- Specificity: Recognizes an epitope within the cysteine-rich region (amino acids 140–301) of the extracellular domain of the human insulin receptor alpha.
Target Information
Biological actions of insulin and IGF-1 are mediated by their respective receptor tyrosine kinases that regulate multiple signaling pathways through phosphorylation cascades.
Insulin/IGF-1 binding to the extracellular domain induces autophosphorylation of downstream target proteins.
Although the insulin receptor and IGF-1 receptor share structural similarities, differences in their ligand-binding and intracellular domains lead to distinct signaling outcomes.
Defects in the insulin receptor (IR) are associated with insulin resistance syndromes, while IGF-1R abnormalities may cause growth retardation. Both signaling pathways are also implicated in cancer development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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