Thermo Fisher Scientific IL-8 (CXCL8) Recombinant Rabbit Monoclonal Antibody (33A9)

Applications and Tested Dilution

Product Specifications

Target Information

Interleukin 8 (IL-8, CXCL8) is a 72 amino acid pro-inflammatory factor belonging to the CXC subfamily of chemokines, bound by the cell surface receptors IL-8RA and IL-8RB. IL-8 functions as a chemoattractant and potent angiogenic factor. Its expression and secretion can be induced by various inflammatory stimuli in many cells, including macrophages and endothelial cells. In endothelial cells, IL-8 is stored in Weibel-Palade bodies.

IL-8, first isolated from osteosarcoma cells, contains the ELR-motif (N-terminal Glu-Leu-Arg sequence) and signals through CXCR1 and CXCR2 receptors. Previous nomenclature includes neutrophil activating protein 1 (NAP-1), granulocyte chemotactic protein 1 (GCP-1), monocyte-derived neutrophil-activating peptide (MONAP), and protein 3-10C. IL-8 and other CXC chemokine family members form a gene cluster on chromosome 4q.

Cancer studies have shown IL-8’s role in angiogenesis and tumor growth, and it is also implicated in bronchiolitis pathogenesis, a common viral respiratory disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.