Thermo Fisher Scientific AGO2 Recombinant Rabbit Monoclonal Antibody (7C2)
AGO2 단백질을 표적하는 재조합 토끼 단클론 항체로, 인간 세포에서 반응성이 확인됨. ICC/IF, Flow Cytometry, ELISA 등에 사용 가능. 높은 특이성과 재현성을 제공하며, 연구용으로 RNA silencing 및 miRNA 관련 연구에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:200 |
| ELISA | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 7C2 |
| Immunogen | A synthesized peptide derived from Human AGO2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.6 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_3092530 |
Target Information
Ago proteins are broadly expressed in somatic cells, associate with miRNAs, and are key actors in various RNA silencing pathways. Among them, only Ago2 displays endonucleolytic or “Slicer” activity, enabling miRNA-directed cleavage of target mRNA when base-pairing is perfect. With partial complementarity, Ago2 inhibits translation through repression rather than cleavage.
Ago2 plays a non-redundant role in small RNA-guided gene silencing, translation repression, and heterochromatinization. As a core component of the RISC complex, AGO2 catalyzes degradation of target mRNAs guided by siRNAs or miRNAs. It also functions as an RNA slicer independently of Dicer and regulates miRNA maturation.
Overexpression of Ago2 has been linked to tumor cell growth and cancer progression. Mouse gene disruption studies show Ago2 is essential for embryonic development and regulates B-lymphoid and erythroid differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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