Thermo Fisher Scientific UCH37 Polyclonal Antibody
Thermo Fisher Scientific의 UCH37 Polyclonal Antibody는 인간 및 마우스에 반응하며, Western blot과 Immunoprecipitation에 적합합니다. 항원 친화 크로마토그래피로 정제된 비결합 액체형 항체로, 1 mg/mL 농도를 유지하며 4°C에서 보관합니다. 암 연구 및 단백질 안정성 연구에 유용합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 150–200 of Human Ubiquitin Carboxyl-Terminal Hydrolase L5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Bovine and Pig
Target Information
UCH-L5 (Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L5), also known as UCH37, is a 329 amino acid protein that edits polyubiquitinated protein substrates.
UCH-L5 may rescue ubiquinated proteins, including oncogenic proteins, from proteasomal degradation, potentially influencing tumor growth.
Through association with Smad7, UCH-L5 can upregulate TGFβ-dependent gene expression by de-ubiquitinating and stabilizing TGFβ RI.
Overexpression of UCH-L5 and other deubiquitinating enzymes has been observed in many cancer cell lines, making them potential targets for cancer therapy.
Four isoforms of UCH-L5 exist due to alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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