Thermo Fisher Scientific NODAL Monoclonal Antibody (1G3)
인간 NODAL 단백질을 인식하는 Mouse IgG2a 단클론 항체. ELISA 검증 완료. 세포 분화 및 암 발달 연구에 적합. 비결합형 액상 형태로 PBS(pH 7.4)에 보존. -20°C 보관, 동결/해동 반복 피해야 함.
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Applications
- ELISA (ELISA): Tested at 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1G3 |
| Immunogen | NODAL (NP_060525.3, 180 a.a. – approximately 279 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
CWPRPPTPPA TNVLLMLYSN LSQEQRQLGG STLLWEAESS WRAQEGQLSW EWGKRHRRHH LPDRSQLCRK VKFQVDFNLI GWGSWIIYPK QYNAYRCEGE
Target Information
NODAL is an important TGF-beta family protein involved in cellular differentiation. It is constitutively expressed in many developing tissues and is associated with differentiation and development of various cancers. NODAL expression is regulated by the Notch signaling pathway, and its dysregulation can contribute to metastatic cancer progression, particularly in melanoma. NODAL abundance can indicate cancer stage and metastatic potential in IHC studies. Interactions with Cripto promote tumor progression. Overexpression of NODAL is also linked to preeclamptic placenta.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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