Thermo Fisher Scientific STAT1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunoprecipitation (IP)

• Tested Dilution: 0.5–2 µL/mg of lysate

Product Specifications

Product Specific Information

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human STAT1.

Target Information

STAT1 (signal transducers and activators of transcription 1) is a member of the STAT family of transcription factors. STAT1 can be activated by interferon-alpha, interferon-gamma, EGF, PDGF, and IL6.
STAT1 regulates genes involved in cell growth, apoptosis, immune responses, and lipid metabolism. It also mediates cell viability in response to various stimuli and pathogen exposure.

The STAT1 gene is located on chromosome 2 and is activated by extracellular signaling molecules such as cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STAT1 translocates to the nucleus to regulate transcription of multiple genes.

Among the seven STAT types (STAT1, STAT3, STAT5a, STAT5b, etc.), STAT1 has a broad activation profile. It responds to ligands including IFN family (IFN-Alpha, IFN-Beta, IFN-Gamma, IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, G-CSF), and receptor tyrosine kinases (EGF, PDGF, CSF-1).
Two alternatively spliced transcript variants encoding distinct isoforms of STAT1 have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.