Thermo Fisher Scientific SPIB Polyclonal Antibody

Applications

Immunoprecipitation (IP)

• Tested Dilution: 4–8 µL/mg of lysate

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human SPIB.

Target Information

Spi-B is a transcription factor belonging to a subfamily of ETS transcription factors with a conserved ETS domain that mediates specific DNA binding. Spi-B may form homotypic interactions and is known to interact with IRF4, CREBBP, EP300, SPI1/PU.1 related, JUN, and TBP.
As a sequence-specific transcriptional activator, it binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer.
Two isoforms of Spi-B are reported. Spi-B is usually expressed in plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells, and promotes their development and blocks viral replication. Spi-B is not expressed in T-cells or granulocytes but may be present in stem cell populations of the liver and B-cells, where it helps in B-cell receptor (BCR) signaling, normal B-cell development, and antigenic stimulation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지