Thermo Fisher Scientific NOV Polyclonal Antibody
Human NOV 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P)에서 1:50~1:100 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 고순도(>95%) 보유. PBS/glycerol buffer에 보존되고, 연구용으로만 사용 가능.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full-length Human NOV (UniProt ID: P48745-1, 1–357 aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720516 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by epitope-specific immunogen affinity chromatography. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
NOV is a member of the CCN family of secreted, cysteine-rich regulatory proteins. The full-length NOV protein contains four structural domains that confer distinct, and sometimes opposing, biological activities. Elevated expression of NOV is associated with certain tumors, including Wilms’ tumor and most nephroblastomas. However, in other tumor types and certain cancer cell lines, increased tumorigenicity and proliferation correlate with decreased NOV expression. Additionally, NOV induces cell adhesion and migration by signaling through specific cell-surface integrins and by binding to heparan sulfate proteoglycans and fibulin 1C. NOV has also been reported to exert proangiogenic activities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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