Thermo Fisher Scientific IL-31 Polyclonal Antibody
IL-31 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunocytochemistry에 적합합니다. Human과 Mouse 시료에 반응하며, 고순도 Affinity chromatography로 정제되었습니다. PBS와 50% glycerol 용액에 보관되며 -20°C에서 안정적으로 저장 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human IL31 (Accession Q6EBC2), corresponding to amino acid residues L53–V103 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900051 |
Product Specific Information
Antibody detects endogenous levels of total IL31.
Target Information
Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells.
IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor.
In response to IL-31 binding, these proteins activate the JAK/STAT and AKT signaling pathways.
RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells.
Overexpression of IL-31 in transgenic mice results in pruritis, alopecia, and skin lesions, and in humans may contribute to atopic dermatitis, suggesting IL-31 as a potential target for antipruritic drug development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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