Thermo Fisher Scientific CD4/CD25 Polyclonal Antibody
CD4/CD25 폴리클로날 항체로 인간, 마우스, 랫트 시료에 반응합니다. Western blot 및 면역세포염색에 적합하며, IL2RA 유래 펩타이드를 면역원으로 사용했습니다. 액상 형태, 1 mg/mL 농도, 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human IL2RA (Accession P01589), corresponding to amino acid residues A242–I272 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900048 |
Product Specific Information
This antibody detects endogenous levels of total IL-2RA/CD25.
Target Information
The CD4 antigen is involved in the recognition of the type II MHC antigen and serves as a receptor for HIV. It is present on most T helper cells and thymocytes, with its cytoplasmic portion associated with p56lck tyrosine kinase. CD4 expression is common in human lymph nodes and tonsils.
CD44 is a type I transmembrane glycoprotein, also known as Phagocytic Glycoprotein-1 (pgp-1) and HCAM. It acts as a receptor for hyaluronate and exists in multiple isoforms due to alternative RNA splicing. The major isoform is expressed on lymphocytes, myeloid cells, and erythrocytes. CD44 is involved in leukocyte adhesion to endothelial cells, stromal cells, and the extracellular matrix.
CD25 (IL2RA) forms part of the high-affinity IL-2 receptor complex along with IL2RB and IL2RG. Homodimeric alpha chains (IL2RA) result in a low-affinity receptor, while beta chain homodimers (IL2RB) yield medium-affinity receptors. Soluble IL2RA has been isolated and results from extracellular proteolysis. Alternative splicing of IL2RA mRNA has been observed, though the functional significance is not fully understood. Mutations in IL2RA are associated with interleukin 2 receptor alpha deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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