Thermo Fisher Scientific Phospho-WWTR1 (Ser89) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Target localization: Cytoplasm, Nucleus
• Immunogen sequence: SHSSP

Target Information

WW domain-containing transcription regulator protein 1 (WWTR1) is a transcriptional coactivator that acts as a downstream regulatory target in the Hippo signaling pathway. This pathway plays a critical role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.
The core kinase cascade involves STK3/MST2 and STK4/MST1, which, with regulatory protein SAV1, phosphorylate and activate LATS1/2 in complex with MOB1. MOB1 subsequently phosphorylates and inactivates YAP1 and WWTR1/TAZ.
WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation, regulates nuclear accumulation of SMADS, and couples them to the transcriptional machinery, including the mediator complex. It also plays a role in embryonic stem-cell self-renewal, cell proliferation, and epithelial-mesenchymal transition.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.