Thermo Fisher Scientific SHANK2 Polyclonal Antibody

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human SHANK2 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SHANK2,uniProtId:Q9UPX8-3,ncbiNodeId:9606,antigenRange:1246-1375,antigenLength:1849,antigenImageFileName:PA5-52524_SHANK2_Q9UPX8-3_Rabbit.svg,antigenImageFileNamePDP:PA5-52524_SHANK2_Q9UPX8-3_Rabbit_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2647261

Product Specific Information

Immunogen sequence: SELNSILQQM NREKLAKPGE GLDSPMGAKS ASLAPRSPEI MSTISGTRST TVTFTVRPGT SQPITLQSRP PDYESRTSGT RRAPSPVVSP TEMNKETLPA PLSAATASPS PALSDVFSLP SQPPSGDLFG

Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 85%.

Target Information

This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.