Thermo Fisher Scientific SHANK2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human SHANK2 protein for research use. Recognizes recombinant SHANK2 antigen with high sequence identity to mouse and rat orthologs. Supplied in liquid form, unconjugated, 0.05 mg/mL concentration. Suitable for stud...
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Thermo Fisher Scientific SHANK2 Polyclonal Antibody
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SHANK2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2647261 |
Product Specific Information
Immunogen sequence:
SELNSILQQM NREKLAKPGE GLDSPMGAKS ASLAPRSPEI MSTISGTRST TVTFTVRPGT SQPITLQSRP PDYESRTSGT RRAPSPVVSP TEMNKETLPA PLSAATASPS PALSDVFSLP SQPPSGDLFG
Antigen sequence identity:
- Mouse: 83%
- Rat: 85%
Target Information
This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats and an SH3 domain. This family member includes a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides, and a sterile alpha motif.
Alternative splicing in Shank genes may regulate the molecular structure and interaction spectrum of Shank proteins in the postsynaptic densities of the adult and developing brain.
Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder.
Alternative splicing results in multiple transcript variants.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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