Thermo Fisher Scientific TNFAIP6 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total TSG6.

Target Information

The TSG6 gene is transcribed in normal fibroblasts and activated by binding of cytokines TNF alpha and IL-1 at AP-1 and NF-IL6 sites in its promoter. TSG-6 is a glycoprotein and a member of the hyaluronan-binding protein family, which includes cartilage link protein, proteoglycan core protein, and adhesion receptor CD44.
TSG-6 is highly homologous to CD44, particularly in the hyaluronic acid-binding domain. It is found in TNF-treated cells and is rapidly activated by TNF alpha, IL-1, and lipopolysaccharide in normal fibroblasts, peripheral blood mononuclear cells, synovial cells, and chondrocytes.
The presence of TSG-6 in synovial fluid suggests a possible role in rheumatoid arthritis. TSG-6 forms a stable complex with components of the serine protease inhibitor, inter-alpha-inhibitor (IαI), and potentiates the inhibitory effect of IαI on the protease activity of plasmin. Through their cooperative inhibitory effect on plasmin, TSG-6 and IαI can modulate the protease network and thus inhibit inflammation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.