Thermo Fisher Scientific SLP76 Polyclonal Antibody
Thermo Fisher Scientific의 SLP76 Polyclonal Antibody는 인간 SLP-76 단백질을 인식하는 염소 유래 다클론 항체입니다. Western blot에 적합하며, 다양한 종과 교차 반응이 예측됩니다. 고순도의 액상 형태로 안정적인 보관이 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.3–1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the N-terminus amino acids ALRNVPFRSEV (aa 2–13) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2136714 |
Product Specific Information
- Predicted to react with bovine, canine, mouse, porcine, and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat.
The SLP-76 locus is localized to human chromosome 5q33, and the gene structure has been partially characterized in mice.
Human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and composed of three modular domains:
- NH2-terminus: Contains an acidic region with a PEST domain and several tyrosine residues phosphorylated after TCR ligation.
- Central region: Proline-rich domain.
- COOH-terminus: SH2 domain.
SLP-76 interacts with several proteins constitutively and inducibly following receptor ligation, functioning as an adaptor or scaffold protein.
Studies using SLP-76 deficient T cell lines or mice indicate that SLP-76 plays a key role in T cell development, activation, mast cell, and platelet function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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