Thermo Fisher Scientific SMAD2 Polyclonal Antibody
SMAD2 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체. Western blot에 적합하며, 세포 증식·분화·신호전달 연구에 활용 가능. 비결합형 액상 형태로 -20°C 보관.
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Thermo Fisher Scientific SMAD2 Polyclonal Antibody
Applications
- Western Blot (WB): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Internal sequence corresponding to amino acids C-SEIWGLSTPNTID |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_1087332 |
Product Specific Information
This antibody is predicted to react with bovine based on sequence homology.
Target Information
SMAD2 (MADH2, MAD2) regulates multiple cellular processes such as cell proliferation, apoptosis, and differentiation. It interacts with TGF-beta receptors via the SMAD anchor for receptor activation, playing a central role in TGF-beta signaling.
Phosphorylation by ERK1 enhances transcriptional activity, while calmodulin negatively regulates it. Upon TGF-beta stimulation, SMAD2 is phosphorylated, dissociates from SARA, and associates with SMAD4 to translocate into the nucleus, forming transcriptional repressor complexes.
SMAD2 can also be phosphorylated by activin type 1 receptor kinase, mediating activin signaling. Alternatively spliced transcript variants encoding SMAD2 have been observed.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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