Thermo Fisher Scientific PTP1B Monoclonal Antibody (4F8F11)
PTP1B 단백질을 인식하는 Mouse monoclonal antibody로 다양한 응용(WB, IHC, ICC, Flow, ELISA)에 사용 가능. 고순도 Protein G 정제, 1 mg/mL 농도. 인간 시료 반응성, 장기 보관 시 -20°C 권장. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4F8F11 |
| Immunogen | Purified recombinant fragment of human PTPN1 (aa 40–246) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898525 |
Product Specific Information
This antibody has been tested in indirect ELISA.
Target Information
PTP1B (PTPN1) is a tyrosine-protein phosphatase acting as a regulator of the endoplasmic reticulum unfolded protein response. It mediates dephosphorylation of EIF2AK3/PERK, thereby inactivating its kinase activity. PTP1B also participates in CKII- and p60c-src-induced signaling cascades, regulates EFNA5-EPHA3 pathways affecting cell reorganization and repulsion, and modulates hepatocyte growth factor receptor (MET) signaling through dephosphorylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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