Thermo Fisher Scientific SHP-1 Monoclonal Antibody (2E9E4)
인간 SHP-1 단백질을 표적으로 하는 마우스 단클론 항체로, WB, ICC/IF, Flow, ELISA에 적합. 단백질 G 정제, 1 mg/mL 농도, PBS 버퍼 및 sodium azide 함유. 연구용으로만 사용 가능.
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Thermo Fisher Scientific SHP-1 Monoclonal Antibody (2E9E4)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2E9E4 |
| Immunogen | Purified recombinant fragment of human PTPN6 (aa 243–541) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898526 |
Product Specific Information
This antibody has been tested in indirect ELISA.
Target Information
SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase expressed primarily in hematopoietic cells. It consists of two SH2 domains, a tyrosine phosphatase catalytic domain, and a carboxy-terminal regulatory domain. SHP-1 removes phosphates from target proteins to downregulate tyrosine kinase-regulated pathways. In hematopoietic cells, its amino-terminal SH2 domain binds phosphorylated erythropoietin receptors (EpoR) to negatively regulate hematopoietic growth. Overexpression in epithelial cells leads to dephosphorylation of the Ros receptor tyrosine kinase, reducing Ros-dependent proliferation and transformation. In myeloid cells, SHP-1 associates with the IL-3R beta chain and downregulates IL-3-induced phosphorylation and proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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