Thermo Fisher Scientific Cyclin T1 Polyclonal Antibody
Cyclin T1 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ELISA, IP 등 다양한 응용에 적합합니다. Cyclin T1/CDK9 복합체 연구 및 HIV-1 전사 활성화 기전 연구에 활용됩니다. 고농도 액상 형태로 제공되며 장기 보관 시 -20°C에서 안정적입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (IHC) | 1:200–1:1,000 |
| ELISA | 1:1,000–1:5,000 |
| Immunoprecipitation (IP) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Cyclin T1 peptide corresponding to an internal region of the human protein conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 75 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2073885 |
Product Specific Information
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
- No reaction was observed against other related cyclins.
Target Information
This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9 (CDK9), forming a major subunit of positive transcription elongation factor b (p-TEFb).
In humans, multiple forms of p-TEFb exist, containing different cyclins along with CDK9. The complex acts as a cofactor of HIV-1 Tat protein, essential for full activation of viral transcription.
Cyclin T1 and CDK9 are involved in transcript elongation via phosphorylation of the RNA polymerase II C-terminal domain. Overexpression of this gene has been linked to tumor growth.
Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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