Thermo Fisher Scientific Dysadherin Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.5–1.5 µg/mL

Product Specifications

Product Specific Information

• Recommended positive controls: The peptide used to generate this antibody is available for purchase (GTX22248-PEP).
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids.
The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator.

• Mouse FXYD5 has been termed RIC (Related to Ion Channel).
• FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme.
• FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems.
• Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane.
• This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production and is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin.
• It also promotes metastasis and has been linked to a variety of cancers.
• Alternative splicing results in multiple transcript variants.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.