Thermo Fisher Scientific MAP2K3 Monoclonal Antibody (OTI5F9), TrueMAB
MAP2K3 단백질을 인식하는 Thermo Fisher의 단클론 항체로, WB, IHC, ICC/IF에 적합합니다. Mouse IgG2b 형식으로, 동결건조 형태이며 PBS buffer에 보관됩니다. Human, Mouse, Rat, Dog 시료에 반응하며 연구용으로 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5F9 |
| Immunogen | Full length human recombinant protein of human MAP2K3 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
MAP2K3 (MEK3) is a dual-specificity protein kinase involved in cellular signal transduction pathways.
It phosphorylates and activates MAPK14/p38-MAPK and is necessary for glucose transporter expression.
Activation of this kinase by insulin or RAS oncogene expression can lead to oncogenic transformation through constitutive MAPK14 activation.
Inhibition of MAP2K3 is implicated in the pathogenesis of Yersinia pseudotuberculosis.
Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported for MEK3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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