Thermo Fisher Scientific TIM-1 Monoclonal Antibody (219211), Alexa Fluor 488

Applications

• Flow Cytometry (Flow): 5 µL per million cells

Product Specifications

Product Specific Information

This antibody does not cross-react with recombinant mouse (rm) TIM-1, rmTIM-2, or rhTIM-3.

Target Information

CD365, also known as T-cell immunoglobulin and mucin domain 1 (Tim-1), is a type I surface glycoprotein composed of an extracellular N-terminal immunoglobulin V-like domain, a mucin domain, and a short cytoplasmic tail.
The endogenous ligand for CD365 is Tim-4. CD365 serves as a receptor or co-receptor for several viruses, including hepatitis A and C viruses, Ebola, Marburg, Dengue, Zika, West Nile, and Japanese encephalitis viruses.
Virus binding occurs via phosphatidylserine exposed on viral envelopes. Polymorphisms within the human CD365 gene (HAVCR1) are associated with infection susceptibility and disease severity. CD365 is also involved in T cell co-stimulation and is primarily expressed in epithelial cells, with high expression in A549, 769-P, and Caco-2 cell lines. Soluble forms of CD365 can arise from metalloproteinase-mediated cleavage of the membrane-bound protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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