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Thermo Fisher Scientific CD146 Monoclonal Antibody (P1H12)
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Thermo Fisher Scientific CD146 Monoclonal Antibody (P1H12)

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인간 CD146 단백질을 표적하는 마우스 단클론 항체로 다양한 면역분석(WB, IHC, ICC, Flow, ELISA, IP)에 사용 가능. 고순도 액상 형태로 제공되며, 1.9 mg/mL 농도. 인간 내피세포 및 멜라노마 연구에 적합.

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MA125100
판매단위
pk
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마지막 업데이트 2025. 08. 05. 오전 08:16
Thermo Fisher Scientific MA125100 CD146 Monoclonal Antibody (P1H12) 50 ul pk판매 단위 pk ·
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630,500원VAT 포함 693,550원

Thermo Fisher Scientific · Thermo Fisher Scientific CD146 Monoclonal Antibody (P1H12)

Thermo Fisher Scientific CD146 Monoclonal Antibody (P1H12)

Applications and Tested Dilution

Application Tested Dilution
Western Blot (WB) 1:1,000
Immunohistochemistry (Frozen) (IHC (F)) Assay-dependent
Immunocytochemistry (ICC/IF) 1:100
Flow Cytometry (Flow) Assay-dependent
ELISA Assay-dependent
Immunoprecipitation (IP) Assay-dependent

Product Specifications

Specification Description
Species Reactivity Human
Host/Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Clone P1H12
Immunogen Human umbilical cord cells
Conjugate Unconjugated
Form Liquid
Concentration 1.9 mg/mL
Purification Purified
Storage Buffer PBS, pH 7.4
Contains 15 mM sodium azide
Storage Conditions Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping Conditions Ambient (domestic); Wet ice (international)
RRID AB_779610

Product Specific Information

  • Recommended positive control: human tongue
  • Store product as a concentrated solution.
  • Centrifuge briefly prior to opening the vial.

Target Information

CD146 (MCAM) is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. It is expressed at cell-cell junctions in endothelial cells and other normal and malignant cell types. CD146 functions as a calcium-independent cell adhesion molecule and may act in signal transduction via recruitment of Fyn kinase, leading to tyrosine phosphorylation of intracellular proteins involved in actin cytoskeleton assembly.

CD146 plays roles in:

  • Endothelial cell adhesion and cohesion
  • Melanoma cell interaction with vascular elements, enhancing tumor spread
  • Neural crest cell adhesion during embryonic development
  • Surface receptor activity triggering tyrosine phosphorylation of FYN and PTK2 and transient intracellular calcium increase

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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