Thermo Fisher Scientific IL17C Polyclonal Antibody, FITC
IL17C 단백질을 인식하는 FITC 결합 Rabbit Polyclonal 항체로, Human 및 비인간 영장류 반응성. WB, IHC, ELISA, IP 등 다양한 응용 가능. 친화 크로마토그래피로 정제되어 높은 순도 유지. 형광 분석용으로 498/517 nm 스펙트럼 특성. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to IL17RC protein common to C1, C2, C5, C8, C9, C11, C12 isoforms |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | –20°C, store in dark |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cytokine that plays a crucial role in innate immunity of the epithelium, including defense against intestinal bacterial pathogens, acting in an autocrine manner. It stimulates the production of antibacterial peptides and proinflammatory molecules via NF-kappa-B and MAPK pathways. Acts synergistically with IL22 in inducing antibacterial peptides such as S100A8, S100A9, REG3A, and REG3G. Synergy also occurs with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, IL17C may have both protective and pathogenic properties—maintaining epithelial homeostasis after inflammation or promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may increase susceptibility to autoimmune diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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