Thermo Fisher Scientific HTR1B Polyclonal Antibody
Rabbit polyclonal antibody against human HTR1B for IHC and ICC/IF applications. Recognizes serotonin receptor subtype 1B with high specificity. Supplied as unconjugated liquid form, 0.05 mg/mL concentration. Suitable for neuroscience and receptor signa...
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- PA565031
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human HTR1B |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2662744 |
Product Specific Information
Immunogen sequence:
MEEPGAQCAPP PPAGSETWVP QANLSSAPSQ NCSAKDYIYQ DS
Highest antigen sequence identity to the following orthologs:
- Mouse: 67%
- Rat: 72%
Target Information
Serotonin (5-hydroxytryptamine, 5-HT) is a serum factor that regulates diverse biological processes in the central and peripheral nervous systems, cardiovascular system, and gastrointestinal system.
Molecular cloning studies have identified five receptors belonging to the 5-HT1 subtypes, which are negatively coupled to adenylyl cyclase.
Radioligand binding studies indicate the presence of 5-HT1B (formerly 5-HT1DbR) sites in the substantia nigra, dorsal subiculum, globus pallidus, and superior collicum.
In situ hybridization studies show 5-HT1BR mRNA abundance in CA1 pyramidal cells of hippocampus, Purkinje cells of cerebellum, olfactory tubercle, subthalamic nucleus, and lower levels in caudate-putamen, cortical areas, thalamic and hypothalamic nuclei.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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