Thermo Fisher Scientific HTR1B Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
MEEPGAQCAPP PPAGSETWVP QANLSSAPSQ NCSAKDYIYQ DS

Highest antigen sequence identity to the following orthologs:

• Mouse: 67%
• Rat: 72%

Target Information

Serotonin (5-hydroxytryptamine, 5-HT) is a serum factor that regulates diverse biological processes in the central and peripheral nervous systems, cardiovascular system, and gastrointestinal system.
Molecular cloning studies have identified five receptors belonging to the 5-HT1 subtypes, which are negatively coupled to adenylyl cyclase.
Radioligand binding studies indicate the presence of 5-HT1B (formerly 5-HT1DbR) sites in the substantia nigra, dorsal subiculum, globus pallidus, and superior collicum.
In situ hybridization studies show 5-HT1BR mRNA abundance in CA1 pyramidal cells of hippocampus, Purkinje cells of cerebellum, olfactory tubercle, subthalamic nucleus, and lower levels in caudate-putamen, cortical areas, thalamic and hypothalamic nuclei.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.