Thermo Fisher Scientific DACH1 Polyclonal Antibody
DACH1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western Blot에 적합합니다. Human, Mouse, Rat 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 1 mg/mL 농도의 액상 형태로 제공되며, 연구용으로 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length Human DACH1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2720784 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is >95% (by SDS-PAGE).
Target Information
DACH1 is a transcription factor involved in the regulation of organogenesis. It acts as a regulator of SIX1, SIX6, and possibly SIX5. DACH1 participates in switching SIX1-mediated repression of precursor cell proliferation to coactivation through EYA3 recruitment. It also interacts with CREBBP for transcriptional activation and represses cyclin-dependent kinase inhibitors such as p27Kip1. Additionally, DACH1 inhibits TGF-beta signaling through interactions with SMAD4 and NCOR1 and binds chromatin DNA via its DACHbox-N domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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