Thermo Fisher Scientific CLCN7 Polyclonal Antibody
CLCN7 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 사용 가능. Human, Mouse, Rat 반응성. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태로 제공. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length Human CLCN7 (aa 1–805, UniProt ID: P51798-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720781 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. Purity is greater than 95% as determined by SDS-PAGE.
Target Information
The CLCN7 gene encodes chloride channel 7, a member of the CLC chloride channel family. These channels are important for chloride ion transport in plasma membranes and intracellular organelles.
Mutations in CLCN7 are associated with osteopetrosis autosomal recessive type 4 (OPTB4, also known as infantile malignant osteopetrosis type 2) and autosomal dominant osteopetrosis type 2 (OPTA2, also called Albers-Schonberg disease or marble bone disease).
Osteopetrosis is a rare genetic disorder characterized by abnormally dense bone due to defective bone resorption. OPTA2 commonly manifests in adolescence or adulthood.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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