Thermo Fisher Scientific CRY2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.

Target Information

Various biochemical, physiological, and behavioral processes display circadian rhythms controlled by an internal biological clock. The central mechanisms of this clock involve an autoregulatory transcription and post-translation-based feedback loop.
Cryptochrome 1 (CRY1) and Cryptochrome 2 (CRY2) are DNA-binding flavoproteins homologous to blue-light receptors and photolyases.

In Drosophila, CRY functions as a photoreceptor for the circadian clock, binding to TIM in a light-dependent manner to regulate its activity. In mammals, CRY1 and CRY2 interact with circadian genes CLOCK and BMAL1, as well as PER1, PER2, and TIM, acting as light-independent components of the circadian clock.

Mutant mice lacking Cry1 or Cry2 exhibit altered locomotor activity rhythms, highlighting the necessity of both proteins for proper circadian synchronization. Double-mutant mice show arrhythmicity in constant darkness, indicating loss of internal clock function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.