Thermo Fisher Scientific SCN8A Polyclonal Antibody
SCN8A 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, 인간·마우스·랫에서 반응합니다. WB 및 ICC/IF에 사용 가능하며, 항원 친화 크로마토그래피로 정제된 고순도 제품입니다. 액상 형태로 4°C 또는 -20°C에서 안정적으로 보관 가능합니다.
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Thermo Fisher Scientific SCN8A Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues in human Na⁺ CP type VIII alpha |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553992 |
Product Specific Information
- Detects endogenous protein at a molecular weight of 225 kDa.
- Purity >95% by SDS-PAGE.
Target Information
The sodium channel protein type 8 subunit alpha (Na⁺ CP type VIII alpha) is a multi-pass transmembrane protein mediating sodium ion permeability of excitable membranes.
Voltage-gated sodium channels consist of:
- A pore-forming alpha subunit
- A noncovalently associated beta1 subunit
- A disulfide-linked beta2 subunit
The beta subunits regulate channel expression, modulate gating, and act as cell adhesion molecules.
Alpha subunits of types I and III are mainly expressed in neuronal cell bodies and proximal processes, while type II alpha subunits are abundant along axons.
Sodium channels are essential for rapid signal transduction and neuronal development.
Defects in the SCN8A gene can impair secondary motoneuron growth, leading to progressive paralysis and early death.
Notice
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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