Thermo Fisher Scientific PCP4/PEP-19 Polyclonal Antibody
PCP4/PEP-19 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC, ICC, ELISA 등 다양한 응용에 적합합니다. Human, Mouse, Rat 반응성이 있으며, Protein A로 정제된 액상 형태입니다. 뇌 신경 관련 연구 및 질환 연구용으로 적합합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human PCP4, amino acids 21–62 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
PCP-4 (Purkinje cell protein 4), also known as PEP-19, is a calmodulin (CaM) regulatory protein highly expressed in neuronal cells. Through its IQ motif, PCP-4 mediates calcium-dependent binding properties of CaM and influences the association/dissociation rates of calcium from the C-terminal domain of CaM. The IQ motif contains a serine residue phosphorylated by all isoforms of protein kinase C (PKC). PCP-4 is implicated in uterine leiomyomas and neurodegenerative disorders such as Alzheimer’s and Huntington’s diseases. Overexpression of PCP-4 is also associated with cerebellar hypoplasia, a characteristic of Down syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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