Thermo Fisher Scientific PTPN5/STEP Polyclonal Antibody
Thermo Fisher Scientific의 PTPN5/STEP 폴리클로날 항체는 인간, 마우스, 랫트 반응성을 가지며 다양한 면역분석(WB, IHC, ICC, ELISA)에 사용 가능합니다. Protein A로 정제된 액상 항체로, 안정적인 보관(-20°C)과 높은 특이성을 제공합니다.
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Thermo Fisher Scientific PTPN5/STEP Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human PTPN5, amino acids 201–300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Reversible phosphorylation of tyrosine residues is a key regulatory mechanism for numerous cellular events such as proliferation, differentiation, gene expression, and migration. Abnormalities in tyrosine phosphorylation are implicated in various human diseases, including cancer and immune deficiencies.
There are at least 107 genes coding for protein tyrosine phosphatases (PTPs) in the human genome. PTPN5 (STEP), PTPRR, and PTPN7 form a family of phosphatases that specifically inactivate MAPKs (mitogen-activated protein kinases). Multiple STEP isoforms exist in the adult rat brain, each showing differential enrichment in regions associated with cognitive, affective, and motor behaviors. These isoforms arise through alternative splicing and possess unique intracellular targets and functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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