Thermo Fisher Scientific TET1 Polyclonal Antibody
TET1 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, 인간·마우스·영장류 시료에 반응합니다. WB, IHC, ICC/IF, IP, ChIP 등 다양한 응용에 적합하며, 항원 친화 크로마토그래피로 정제된 고품질 제품입니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific TET1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
| Immunoprecipitation (IP) | Assay-dependent |
| ChIP assay (ChIP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human TET1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792629 |
Product Specific Information
- Keep as a concentrated solution.
- Positive Control: 293T, A431, HeLa, HepG2, 293T tagged-hTET1, DDDDK-human TET1-transfected 293T.
- Centrifuge briefly prior to opening the vial.
Target Information
TET1 is a dioxygenase that specifically binds methylcytosine (5mC), a minor base in mammalian DNA found in repetitive DNA elements crucial for retrotransposon silencing and mammalian development. It catalyzes the conversion of 5mC to 5-hydroxymethylcytosine (hmC). Although the clear function of hmC is still unclear, it may influence chromatin structure, recruit specific factors, or serve as an intermediate in cytosine demethylation. hmC is present in embryonic stem cells and enriched in the brain, particularly in Purkinje neurons. TET1 may play a role in fetal development of heart, lung, and brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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