Thermo Fisher Scientific Apolipoprotein B/APOB Monoclonal Antibody (APOB/4332)
인간 Apolipoprotein B(APOB)에 특이적인 Mouse 단일클론 항체로, IHC 및 Peptide Array 등 다양한 응용에 적합. 단백질 A/G로 정제된 액상 형태이며, 보존제가 포함되지 않음. 연구용으로만 사용 가능.
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Thermo Fisher Scientific Apolipoprotein B/APOB Monoclonal Antibody (APOB/4332)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | APOB/4332 |
| Immunogen | Human recombinant APOB protein fragment (around aa 592–689) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Apolipoprotein B (apo B) in human plasma is a major protein of low-density lipoproteins (LDL) with a molecular mass of approximately 260–500 kDa. It binds to specific receptors on cell membranes and is involved in the removal of LDL and very low-density lipoprotein (VLDL) cholesterol from circulation.
LDL mediates the uptake and clearance of cholesterol from the bloodstream. Oxidized LDL is found in atherosclerotic lesions and is recognized by macrophages via scavenger receptors A and CD36.
Apolipoprotein B is synthesized mainly in the liver and is a key component of LDL, VLDL, and lipoprotein(a). Elevated levels are associated with premature atherosclerosis.
Two main isoforms exist: apoB-48 and apoB-100, produced by RNA editing of a single gene transcript. Mutations can lead to disorders such as hypobetalipoproteinemia and hypercholesterolemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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