Thermo Fisher Scientific CMKLR1 Polyclonal Antibody
CMKLR1 단백질을 검출하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 사람, 생쥐, 랫트 반응성. Western blot에 적합하며, 고순도 항원 친화 크로마토그래피 정제. 액상 형태로 -20°C 보관.
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Thermo Fisher Scientific CMKLR1 Polyclonal Antibody
Applications
- Western Blot (WB): 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from internal region of human CMKLR1 (239–266, UniProt ID: Q99788-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635364 |
Product Specific Information
This antibody detects endogenous levels of total CHEMR23 / CMKLR1 protein.
Target Information
Chemokine-like receptor 1 (CMKLR1) acts as a receptor for the chemoattractant adipokine chemerin (RARRES2) and for the omega-3 fatty acid-derived molecule resolvin E1. Interaction with RARRES2 activates intracellular signaling molecules such as SKY, MAPK1/3 (ERK1/2), MAPK14 (p38 MAPK), and PI3K, resulting in diverse biological effects including immune response modulation, adipogenesis enhancement, and angiogenesis. Resolvin E1 reduces cytokine production in macrophages by inhibiting MAPK1/3 (ERK1/2) and NF-κB activation. CMKLR1 also positively regulates adipocyte metabolism and serves as a co-receptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR, SIVSM62A) and a primary HIV-1 strain (92UG024-2).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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