Thermo Fisher Scientific CDCA2 Polyclonal Antibody
CDCA2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 적합합니다. 인간 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS/glycerol 완충액에 보관되며, 세포 주기 및 암 연구에 유용합니다.
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Applications
- Western Blot (WB): 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from C-terminal of human CDCA2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635362 |
Product Specific Information
This antibody detects endogenous levels of total CDCA2 protein.
Target Information
Cell division cycle associated 2 (CDCA2, also known as Repo-Man) is a cell-cycle protein that recruits protein phosphatase 1 (PP1) to mitotic chromatin at anaphase onset, essential for cell proliferation. Phosphorylation of CDCA2 at Ser893 by Aurora B inhibits its function, while dephosphorylation by PP2A allows reformation of the CDCA2/PP1 complex, which is required for chromatin binding and histone H3 dephosphorylation.
The CDCA2/PP1 complex is also involved in nuclear envelope reformation during mitotic exit and may play a role in DNA repair. Increased CDCA2 expression has been observed in several cancers, including melanoma, neuroblastoma, squamous cell carcinoma, and synovial sarcomas, suggesting its potential as a prognostic marker.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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