Thermo Fisher Scientific Phospho-Chk1 (Ser317) Recombinant Rabbit Monoclonal Antibody (Chk1S317-G1), PE
PE 형광 표지된 Phospho-Chk1 (Ser317) 항체로 인간 및 마우스 시료에 반응합니다. 재조합 토끼 단클론 항체로 높은 특이성과 일관성을 제공합니다. Flow Cytometry에 적합하며, 단백질 A/G로 정제되었습니다. 4°C에서 보관합니다.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 5 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | Chk1S317-G1 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Ser317 of human phospho Chk1 |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897001 |
Additional Formats
- Unconjugated (Cat. MA5-37065)
- APC (Cat. MA5-37068)
- FITC (Cat. MA5-37067)
- Custom conjugation available upon request
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages:
- High specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broad immunoreactivity due to large rabbit immune repertoire
Target Information
CHEK1 (CHK1) is a serine/threonine protein kinase involved in maintaining DNA integrity by preventing replication when DNA damage occurs. It plays a key role in the DNA damage-induced checkpoint network and ensures genomic stability under genotoxic stress.
When CHK1 function is inhibited, p53-deficient cancer cells undergo mitotic catastrophe and apoptosis, while normal cells remain arrested in G1 phase. Therefore, CHK1 is considered an attractive therapeutic target for cancer treatment, particularly in p53-deficient tumors.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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