Thermo Fisher Scientific SOCS1 Polyclonal Antibody
SOCS1 단백질에 특이적인 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간 및 마우스 시료에서 반응하며 Western blot에 적합. 비결합형 액상 형태로 제공되며, 단기 4°C, 장기 -20°C 보관 가능. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
- Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 54–68 of human SOCS1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Whole serum/PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2239647 |
Product Specific Information
- Suggested positive control: Ramos or RAW cells.
Target Information
Suppressor of cytokine signaling (SOCS) and cytokine-inducible SH2 proteins are intracellular regulators of cytokine responses in immune cells.
SOCS1 inhibits JAK tyrosine kinase activity, thereby modulating type I and II cytokine receptor signaling.
It also functions as an E3 ubiquitin ligase, promoting degradation of target proteins via polyubiquitination.
Through this mechanism, SOCS1 negatively regulates Toll-like receptor signaling (TLR2 and TLR4) by mediating degradation of the adaptor protein TIRAP.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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