Thermo Fisher Scientific IL-12 p40 Polyclonal Antibody
IL-12 p40 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 실험에 적합합니다. Human, Mouse, Rat 반응성을 가지며, 고순도의 Affinity chromatography로 정제되었습니다. PBS/50% glycerol buffer에 보관하며, 연구용으로 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
- Publications: References
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
- Publications: References
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human IL12B (Accession P29460), corresponding to amino acid residues E257–S307 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900038 |
Product Specific Information
Antibody detects endogenous levels of total IL12B.
Target Information
IL12B (IL-12 p40) encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells and exhibits broad biological activities.
Interleukin 12 is a disulfide-linked heterodimer composed of a 40 kDa cytokine receptor-like subunit encoded by IL12B and a 35 kDa subunit encoded by IL12A.
It is expressed by activated macrophages and serves as an essential inducer of Th1 cell development.
Overexpression of this gene has been observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role in disease pathogenesis.
Promoter polymorphisms of IL12B have been associated with the severity of atopic and non-atopic asthma in children.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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