Thermo Fisher Scientific Resistin Polyclonal Antibody
Rabbit 유래의 Polyclonal 항체로 인간 Resistin 단백질을 인식합니다. Western blot에 최적화되어 있으며, PBS(pH 7.4) 용액에 보존됩니다. 단백질 A로 정제되었고 방부제가 포함되어 있지 않습니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to aa 94–102 of human resistin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.0 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Adipose tissue functions as an energy reserve and is tightly regulated. Adipocytes secrete several physiologically important proteins, such as lipoprotein lipase (LPL), leptin, Acrp30, perilipin, and resistin.
Resistin, also known as Adipocyte Secreted Factor (ADSF) and FIZZ3, is a cytokine specifically secreted by adipocytes. Although its function is not fully understood, resistin appears to play paracrine roles and is implicated in type 2 diabetes.
In obese, diabetic mice, serum resistin levels are elevated and antagonize insulin action. Resistin induces insulin resistance and glucose intolerance in mice. Its gene expression requires C/EBP alpha and is modulated by coactivators CBP and p300, which acetylate histones at the resistin promoter, activating chromatin for transcription. PPAR gamma and RXR ligands have been shown to downregulate resistin expression in adipocytes.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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