Thermo Fisher Scientific WIPI2 Monoclonal Antibody (2A2)

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

1-2 µg/10^6 cells

-

ELISA (ELISA)

Assay-dependent

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

2A2

Immunogen

Recombinant fragment (around aa 418-436) of human WIPI2 protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:WIPI2,uniProtId:Q9Y4P8-1,ncbiNodeId:9606,antigenRange:418-436,antigenLength:454,antigenImageFileName:26100-MSM1-P1ABX_WIPI2_Q9Y4P8-1_House_mouse.svg,antigenImageFileNamePDP:26100-MSM1-P1ABX_WIPI2_Q9Y4P8-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A/G

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

Target Information

WD repeat proteins play a role in many essential biologic functions, regulating the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. WIPI2, also known as ATG18B or ATG21, is a human homolog to yeast ATG18 and contains three WD repeats and has a 7-bladed propeller structure with a conserved motif that facilitates its interaction with other proteins. It is recruited to early autophagosomal structures along with Atg16L and ULK1 and is required for the formation of LC3-positive autophagosomes. Along with the highly related WIPI1, WIPI2 is found at the plasma membrane in addition to autophagosomal membranes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.