Thermo Fisher Scientific Resistin Polyclonal Antibody
Thermo Fisher Scientific의 Resistin Polyclonal Antibody는 인간 유래 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot에 최적화되어 있습니다. 합성 펩타이드(aa 79-90)를 면역원으로 사용하며, Protein A 정제 방식으로 제조되었습니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to aa 79–90 of human resistin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.0 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Adipose tissue acts as an energy reserve and is tightly regulated. Adipocytes produce and secrete several physiologically important proteins, including lipoprotein lipase (LPL), leptin, Acrp30, perilipin, and resistin.
Resistin, also known as Adipocyte Secreted Factor (ADSF) and FIZZ3, is a cytokine specifically secreted by adipocytes. Although its function is not fully understood, it plays key paracrine roles and is implicated in type 2 diabetes.
Studies have shown:
- Serum resistin levels are elevated in obese, diabetic mice, antagonizing insulin action.
- Resistin induces insulin resistance and glucose intolerance in mice.
- Resistin gene expression requires C/EBP alpha and is influenced by coactivators CBP and p300, which acetylate histones at the resistin promoter, activating chromatin for transcription.
- PPAR gamma and RXR ligands downregulate resistin expression in adipocytes.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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