Thermo Fisher Scientific Calponin 1 Polyclonal Antibody
Calponin 1 단백질을 인식하는 염소 유래 polyclonal 항체로, 인체 시료에 반응. IHC(P)에서 3–6 µg/mL 농도로 사용 가능. 액상 형태로 공급되며, TBS(pH 7.3) 및 0.5% BSA 포함. 평활근 수축 조절 연구 및 조직학적 분석에 적합.
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Applications and Tested Dilution
- Application: Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 3–6 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-KRQIFEPGLGMEH (aa 225–237) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933139 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
Calponin is a thin filament-associated protein involved in the regulation and modulation of smooth muscle contraction. It binds actin, calmodulin, troponin C, and tropomyosin, and is expressed in smooth muscle and tissues containing significant amounts of smooth muscle. Two isoforms exist (34 kDa and 29 kDa). The 29 kDa isoform is primarily expressed in urogenital tract muscle.
Calponin expression has been observed in myoepithelial cells from benign and malignant breast lesions. It stains smooth muscle, myoepithelial cells, myofibroblasts, keratinocytes, and nerve fibers. It is useful in identifying myoepithelial cells in breast lesions and differentiating collagenous spherulosis (positive) from adenoid cystic carcinoma. Adenoid cystic carcinoma in salivary gland tumors is also calponin positive.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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